And until you have got a doctor-diagnosed deficiency in any of those nutrients that you simply can’t fill with food alone, there’s no actual have to supplement in any respect. "At best, tremendous-high doses of nutrients are shopping for you expensive urine, and at worst, they might contribute to the event of chronic diseases," she says. While research show supplementing with high doses does help build muscle mass and improve power over time, it’s not pre-workout in the strict sense, in that timing doesn’t really matter. Taking smaller doses more steadily throughout the day might also be an choice, but it is best to talk about any modifications in your medicine timing or dosage together with your physician earlier than experimenting on your own. For instance, a 2017 research within the Journal of Clinical Oncology discovered that long-term supplementation with high doses of vitamin B6 and B12 might considerably enhance the chance of lung cancer in males