This family comprises only one protein, SET7/9, which mono-methylates histone at H3K4 ninety two KMT7 was discovered to methylate, in addition to histone, quite a few non-histone proteins, including p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear issue kappaB (NFκB), and parts of the TATA binding protein (TBP) complex, TBP-associated components TAF10 and TAF7 93 The consensus recognition sequence in substrates for SET7-mediated lysine methylation, Ok/R-S/T-K (target lysine is daring), is also recognized by the H3K4 demethylase KDM1A/LSD1, which is able to removing the methyl mark on most of those substrates 17 , 94 Subsequently KMT7/KDM1A has emerged as a classic mannequin for dynamic lysine methylation of each histone and non-histone proteins.

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N, amino terminus